Motif ID: FOX{F1,F2,J1}.p2

Z-value: 1.938

Transcription factors associated with FOX{F1,F2,J1}.p2:

NameEntrezDescription
Foxf1a 15227 forkhead box F1a
Foxf2 14238 forkhead box F2
Foxj1 15223 forkhead box J1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
Foxf2chr13_+_317177720.492.4e-03Click!
Foxf1achr8_+_1236082520.382.4e-02Click!
Foxj1chr11_-_116196604-0.335.0e-02Click!


Activity profile for motif FOX{F1,F2,J1}.p2.

activity profile for motif FOX{F1,F2,J1}.p2


Sorted Z-values histogram for motif FOX{F1,F2,J1}.p2

Sorted Z-values for motif FOX{F1,F2,J1}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{F1,F2,J1}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Description
chr5_-_104542751 33.397 Sparcl1
SPARC-like 1
chr5_-_104542598 31.949 Sparcl1
SPARC-like 1
chr5_-_104542729 29.348 Sparcl1
SPARC-like 1
chr5_-_104542641 25.503 Sparcl1
SPARC-like 1
chr8_-_87297283 20.913 Nfix
nuclear factor I/X
chr14_-_52533039 20.303 Ndrg2
N-myc downstream regulated gene 2
chr14_-_52532988 19.776 Ndrg2
N-myc downstream regulated gene 2
chr14_+_120674921 16.423 Mbnl2
muscleblind-like 2
chr15_+_3220994 14.870 Sepp1
selenoprotein P, plasma, 1
chr8_+_46970814 14.033 NM_016798
Pdlim3
PDZ and LIM domain 3
chr15_+_3220999 11.612 Sepp1
selenoprotein P, plasma, 1
chr15_-_88808967 10.514 NM_133241
Mlc1
megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
chr4_+_101180580 9.478 NM_001164584
NM_001164585
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr8_-_127093601 9.034 NM_007428
Agt
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr2_-_71205587 8.878 NM_172436
Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr15_+_91991704 8.868 NM_001159647
Cntn1
contactin 1
chr19_+_53403902 8.643 NM_010847
Mxi1
Max interacting protein 1
chr12_-_85791897 8.524 NM_134042
Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr18_+_23468585 8.234 Dtna
dystrobrevin alpha
chr18_+_23468655 8.032 Dtna
dystrobrevin alpha
chr12_-_85791928 7.878 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr2_+_121184334 7.832 NM_009897
Ckmt1
creatine kinase, mitochondrial 1, ubiquitous
chr15_-_66801198 7.821 NM_008681
Ndrg1
N-myc downstream regulated gene 1
chr2_+_138104219 7.689 NM_145534
Btbd3
BTB (POZ) domain containing 3
chr2_-_148701164 7.614 Cst3
cystatin C
chr16_-_22439642 7.461 NM_023794
Etv5
ets variant gene 5
chr15_+_99223622 7.262 NM_001171035
Tmbim6
transmembrane BAX inhibitor motif containing 6
chr14_+_120674933 7.056 Mbnl2
muscleblind-like 2
chr1_-_134603848 6.991 NM_001160318
Nfasc
neurofascin
chr4_+_101180625 6.645 Dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr14_+_120674939 6.577 Mbnl2
muscleblind-like 2
chr7_+_53039273 5.971 NM_001005511
Lmtk3
lemur tyrosine kinase 3
chr8_-_70342105 5.906 NM_027626
Psd3
pleckstrin and Sec7 domain containing 3
chr7_-_26460133 5.870 Tmem91
transmembrane protein 91
chr7_-_87547589 5.796 NM_011046
Furin
furin (paired basic amino acid cleaving enzyme)
chr15_+_99223377 5.644 NM_001171034
NM_001171036
NM_026669
Tmbim6


transmembrane BAX inhibitor motif containing 6


chrX_+_7496899 5.577 NM_013892
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chrM_+_409 5.459


chr6_+_129483295 5.297 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chrX_-_149078963 5.281 Shroom2
shroom family member 2
chr3_-_9833502 5.086 NM_001195031
NM_053182
Pag1

phosphoprotein associated with glycosphingolipid microdomains 1

chr7_-_86293852 5.064 NM_001045489
NM_008594
Mfge8

milk fat globule-EGF factor 8 protein

chr2_-_73498303 5.044 NM_001166604
NM_175752
Chn1

chimerin (chimaerin) 1

chr11_-_70053281 4.920 NM_173742
Rnasek
ribonuclease, RNase K
chr19_-_17912073 4.908 NM_001163144
NM_001190483
Pcsk5

proprotein convertase subtilisin/kexin type 5

chr3_+_7366586 4.894 NM_008862
Pkia
protein kinase inhibitor, alpha
chr7_-_107805365 4.812 Plekhb1
pleckstrin homology domain containing, family B (evectins) member 1
chr9_-_102256962 4.794 NM_001168296
NM_173447
Ephb1

Eph receptor B1

chr7_-_147268395 4.789 NM_001190385
NM_026769
Caly

calcyon neuron-specific vesicular protein

chr11_+_69435553 4.750 NM_026991
Sat2
spermidine/spermine N1-acetyl transferase 2
chr2_-_73150559 4.630 NM_025854
Cir1
corepressor interacting with RBPJ, 1
chr18_-_39078304 4.430 NM_010197
Fgf1
fibroblast growth factor 1
chr8_+_46970860 4.317 Pdlim3
PDZ and LIM domain 3
chr5_+_139899132 4.286 NM_029771
Gpr30
G protein-coupled receptor 30
chr3_-_27795287 4.178 NM_001164437
Tmem212
transmembrane protein 212
chr14_-_73785035 4.101 Itm2b
integral membrane protein 2B
chr10_-_126959397 4.096 Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr6_-_88791829 4.080 Abtb1
ankyrin repeat and BTB (POZ) domain containing 1
chr3_+_52072302 4.012 Foxo1
forkhead box O1
chr14_+_120674976 3.934 Mbnl2
muscleblind-like 2
chr10_-_126959446 3.862 NM_028230
Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr7_-_26460180 3.855 NM_177102
Tmem91
transmembrane protein 91
chr6_+_141472906 3.830 NM_001177772
NM_021471
Slco1c1

solute carrier organic anion transporter family, member 1c1

chr2_-_71205805 3.801 Slc25a12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
chr1_-_182126032 3.764 NM_023341
Adck3
aarF domain containing kinase 3
chr6_-_113841356 3.714 NM_001036684
Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chrX_+_21061748 3.698 NM_007429
Agtr2
angiotensin II receptor, type 2
chr6_-_113841295 3.637 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr16_-_85120798 3.605 App
amyloid beta (A4) precursor protein
chr2_-_170232008 3.552 Bcas1
breast carcinoma amplified sequence 1
chr6_+_22825464 3.533 NM_001081306
Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr11_+_78137699 3.505 NM_009657
Aldoc
aldolase C, fructose-bisphosphate
chr1_-_137064124 3.499 NM_134438
Gpr37l1
G protein-coupled receptor 37-like 1
chr2_+_164311755 3.499 NM_026797
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chrX_+_7299332 3.495 Wdr45
WD repeat domain 45
chr19_+_3935169 3.493 NM_001161428
NM_019449
Unc93b1

unc-93 homolog B1 (C. elegans)

chr1_+_91351435 3.451 Agap1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr5_+_136559785 3.330 NM_001039103
NM_133914
Rasa4

RAS p21 protein activator 4

chr19_-_59150001 3.209 4930506M07Rik
RIKEN cDNA 4930506M07 gene
chr2_-_32702610 3.176 Stxbp1
syntaxin binding protein 1
chr5_-_147032932 3.054 NM_028774
Rnf6
ring finger protein (C3H2C3 type) 6
chr15_-_66801093 3.004 Ndrg1
N-myc downstream regulated gene 1
chr12_-_73171976 2.963 NM_181752
Gpr135
G protein-coupled receptor 135
chr11_-_50024275 2.927 NM_011018
Sqstm1
sequestosome 1
chr13_-_61037894 2.900 NM_001145799
Ctla2a
cytotoxic T lymphocyte-associated protein 2 alpha
chr16_-_31314534 2.882 NM_007470
Apod
apolipoprotein D
chr2_+_180701920 2.875 NM_001177707
NM_001177708
NM_001177709
NM_001177710
NM_145760
Arfgap1




ADP-ribosylation factor GTPase activating protein 1




chr8_+_65430028 2.844 NM_023689
Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr5_-_138042267 2.829 NM_030037
Mospd3
motile sperm domain containing 3
chr12_+_85792371 2.803 NM_173756
Lin52
lin-52 homolog (C. elegans)
chr3_-_146433544 2.768 NM_001164199
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chrM_-_622 2.768


chr9_-_45763300 2.727 NM_172257
Sidt2
SID1 transmembrane family, member 2
chr14_-_104243541 2.718 Ednrb
endothelin receptor type B
chr16_+_5885447 2.716 Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr2_+_73150702 2.667 NM_029022
Scrn3
secernin 3
chr7_+_31076771 2.663 NM_001081114
Clip3
CAP-GLY domain containing linker protein 3
chr8_+_73051625 2.655 NM_001111066
NM_010223
Fkbp8

FK506 binding protein 8

chr11_-_54769601 2.623 Tnip1
TNFAIP3 interacting protein 1
chr18_-_60908267 2.591 Ndst1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr18_+_37133455 2.575 NM_009957
Pcdha7
protocadherin alpha 7
chr19_-_4012654 2.536 Ndufv1
NADH dehydrogenase (ubiquinone) flavoprotein 1
chr2_+_65458814 2.534


chr15_+_3224767 2.523 Sepp1
selenoprotein P, plasma, 1
chr19_-_45858019 2.497 Mgea5
meningioma expressed antigen 5 (hyaluronidase)
chr9_+_113721698 2.488 NM_001081960
NM_029633
Clasp2

CLIP associating protein 2

chr11_-_54769546 2.482 Tnip1
TNFAIP3 interacting protein 1
chrX_+_117403867 2.470 NM_001081385
Pcdh11x
protocadherin 11 X-linked
chr11_-_118355393 2.419


chr2_+_158201373 2.417 NM_175692
Snhg11
small nucleolar RNA host gene 11
chr10_-_57252252 2.394 NM_019760
Serinc1
serine incorporator 1
chr2_+_91570249 2.387 NM_001080754
NM_172669
Ambra1

autophagy/beclin 1 regulator 1

chr17_+_75835208 2.360 NM_001166493
Rasgrp3
RAS, guanyl releasing protein 3
chr11_+_102291759 2.348 Grn
granulin
chr4_-_96258099 2.338 NM_028979
Cyp2j9
cytochrome P450, family 2, subfamily j, polypeptide 9
chr15_+_35301320 2.337 Vps13b
vacuolar protein sorting 13B (yeast)
chr1_-_196957466 2.326 Cr1l
complement component (3b/4b) receptor 1-like
chr11_+_98603186 2.323 NM_178060
Thra
thyroid hormone receptor alpha
chr13_+_59234737 2.306 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr7_+_31076852 2.303 Clip3
CAP-GLY domain containing linker protein 3
chr3_-_59014800 2.272 NM_028808
P2ry13
purinergic receptor P2Y, G-protein coupled 13
chr5_+_130505237 2.266 Crcp
calcitonin gene-related peptide-receptor component protein
chr3_+_125106995 2.260 NM_022565
Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr2_-_32702729 2.258 NM_009295
NM_001113569
Stxbp1

syntaxin binding protein 1

chrX_+_7299358 2.250 NM_172372
Wdr45
WD repeat domain 45
chr17_-_80295336 2.240 NM_019717
NM_178050
Atl2

atlastin GTPase 2

chr2_-_168427037 2.215 NM_001037178
Nfatc2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
chr11_+_31900378 2.143 NM_008741
Nsg2
neuron specific gene family member 2
chr15_-_42508294 2.138 NM_009640
Angpt1
angiopoietin 1
chr14_+_112074336 2.129 NM_198865
Slitrk5
SLIT and NTRK-like family, member 5
chr3_+_96361879 2.119 NM_001009935
NM_023719
Txnip

thioredoxin interacting protein

chr10_+_57351786 2.119 NM_001039051
NM_008863
Pkib

protein kinase inhibitor beta, cAMP dependent, testis specific

chr10_+_56097078 2.118 NM_010288
Gja1
gap junction protein, alpha 1
chr13_-_104710374 2.117 NM_001005868
NM_021563
Erbb2ip

Erbb2 interacting protein

chr12_+_77182878 2.110 Syne2
synaptic nuclear envelope 2
chr12_-_32184404 2.100 NM_134048
Cbll1
Casitas B-lineage lymphoma-like 1
chr9_-_106588220 2.085 NM_001081654
Tex264
testis expressed gene 264
chr12_+_70397795 2.075


chr6_-_88791875 2.066 Abtb1
ankyrin repeat and BTB (POZ) domain containing 1
chr18_-_13021181 2.034 Osbpl1a
oxysterol binding protein-like 1A
chr19_-_5797749 2.026 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr16_-_4679664 2.012 NM_030205
Coro7
coronin 7
chr7_+_116154373 2.009 NM_021885
Tub
tubby candidate gene
chr9_+_110235922 1.994 Scap
SREBF chaperone
chr3_-_146433200 1.993 NM_001164198
Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr12_+_38607291 1.985 NM_178681
Dgkb
diacylglycerol kinase, beta
chr14_+_120674913 1.969 Mbnl2
muscleblind-like 2
chr11_-_51449228 1.958 Rmnd5b
required for meiotic nuclear division 5 homolog B (S. cerevisiae)
chr5_-_92777875 1.947 NM_021274
Cxcl10
chemokine (C-X-C motif) ligand 10
chr11_-_68825972 1.923


chr14_+_26484518 1.894 Gm10397
predicted gene 10397
chr19_+_8815893 1.893 NM_001167799
Stx5a
syntaxin 5A
chr9_-_30957394 1.889


chr8_+_46744023 1.883 Sorbs2
sorbin and SH3 domain containing 2
chr9_-_56995928 1.864 Neil1
nei endonuclease VIII-like 1 (E. coli)
chr2_-_127618207 1.862 1500011K16Rik
RIKEN cDNA 1500011K16 gene
chr15_-_8584897 1.860 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_+_78744328 1.856 NM_020271
Pdxp
pyridoxal (pyridoxine, vitamin B6) phosphatase
chr8_+_96335202 1.851 Gnao1
guanine nucleotide binding protein, alpha O
chr5_+_13125413 1.817 LOC100503462
hypothetical LOC100503462
chr15_-_58046380 1.799 Fbxo32
F-box protein 32
chr15_-_54751515 1.797 NM_001136077
NM_015744
Enpp2

ectonucleotide pyrophosphatase/phosphodiesterase 2

chr6_-_58974400 1.795 NM_153574
Fam13a
family with sequence similarity 13, member A
chr14_+_56159204 1.790 Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr14_-_52533114 1.771 NM_001145959
NM_013864
Ndrg2

N-myc downstream regulated gene 2

chr19_-_45857958 1.733 Mgea5
meningioma expressed antigen 5 (hyaluronidase)
chr16_+_49699314 1.732 NM_028680
Ift57
intraflagellar transport 57 homolog (Chlamydomonas)
chr11_+_22872062 1.732 Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr11_-_60166321 1.709 Tom1l2
target of myb1-like 2 (chicken)
chr1_+_75139300 1.703 NM_170755
Fam134a
family with sequence similarity 134, member A
chr16_-_45408997 1.671 NM_010818
Cd200
2300009N04Rik
CD200 antigen
RIKEN cDNA 2300009N04 gene
chr4_+_9196439 1.667 NM_028940
Clvs1
clavesin 1
chr12_-_113749363 1.665 NM_178915
Tmem179
transmembrane protein 179
chr6_-_60779848 1.662 NM_009221
Snca
synuclein, alpha
chr15_-_63891810 1.647 NM_144846
Fam49b
family with sequence similarity 49, member B
chr3_-_97692613 1.647 NM_001039376
Pde4dip
phosphodiesterase 4D interacting protein (myomegalin)
chr4_-_35792385 1.642 NM_001166001
NM_175516
Lingo2

leucine rich repeat and Ig domain containing 2

chr10_+_78243274 1.631 Slc1a6
solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
chr15_-_54109855 1.614 NM_008764
Tnfrsf11b
tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
chrM_+_3320 1.600


chr6_+_53523365 1.581 NM_172728
Creb5
cAMP responsive element binding protein 5
chr10_-_57252184 1.568 Serinc1
serine incorporator 1
chr14_-_122097583 1.562 NM_001081039
Dock9
dedicator of cytokinesis 9
chr9_+_5345475 1.540 NM_009808
Casp12
caspase 12
chr10_-_127617294 1.530 NM_001039080
Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_+_102289600 1.515 NM_001170911
NM_025385
Prr13

proline rich 13

chr6_-_71390481 1.509 Rmnd5a
required for meiotic nuclear division 5 homolog A (S. cerevisiae)
chr11_+_22872016 1.507 NM_011663
Zrsr1
zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1
chr6_-_148392841 1.502 NM_198967
Tmtc1
transmembrane and tetratricopeptide repeat containing 1
chr2_-_152657392 1.486 Bcl2l1
BCL2-like 1
chr19_+_7631935 1.468 NM_139269
Pla2g16
phospholipase A2, group XVI
chr1_+_51345952 1.467 NM_138741
Sdpr
serum deprivation response
chr7_+_134072351 1.458 NM_172747
Kctd13
potassium channel tetramerisation domain containing 13
chr4_+_154927385 1.448 Gnb1
guanine nucleotide binding protein (G protein), beta 1
chr8_+_73051648 1.436 Fkbp8
FK506 binding protein 8
chr18_+_37678006 1.434 NM_053147
Pcdhb22
protocadherin beta 22
chr4_+_97439255 1.425 Nfia
A130013F12Rik
nuclear factor I/A
RIKEN cDNA A130013F12 gene
chr10_-_59414516 1.421 NM_029083
Ddit4
DNA-damage-inducible transcript 4
chr16_+_49913305 1.419 Cd47
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
chr11_+_16157685 1.411 NM_145967
Vstm2a
V-set and transmembrane domain containing 2A

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment p-value GO term description
3.21 1.52e-05 GO:0032879 regulation of localization
13.59 1.25e-04 GO:0045807 positive regulation of endocytosis
2.78 3.45e-04 GO:0050790 regulation of catalytic activity
2.10 9.54e-04 GO:0048519 negative regulation of biological process
1.98 1.13e-03 GO:0048518 positive regulation of biological process
2.15 1.33e-03 GO:0048523 negative regulation of cellular process
3.22 1.44e-03 GO:0051049 regulation of transport
2.03 1.89e-03 GO:0048522 positive regulation of cellular process
2.81 1.94e-03 GO:0051641 cellular localization
3.80 2.77e-03 GO:0051336 regulation of hydrolase activity
2.38 3.88e-03 GO:0065009 regulation of molecular function
8.55 4.55e-03 GO:0030100 regulation of endocytosis
2.53 8.42e-03 GO:0007399 nervous system development
4.11 8.95e-03 GO:0009628 response to abiotic stimulus
4.08 9.84e-03 GO:0051050 positive regulation of transport
3.80 1.08e-02 GO:0016044 cellular membrane organization
3.78 1.15e-02 GO:0061024 membrane organization
1.79 1.24e-02 GO:0051179 localization
2.66 1.25e-02 GO:0043067 regulation of programmed cell death
1.88 1.45e-02 GO:0051234 establishment of localization
2.59 1.92e-02 GO:0010941 regulation of cell death
3.00 2.15e-02 GO:0008219 cell death
1.92 2.18e-02 GO:0048731 system development
3.24 2.21e-02 GO:0009605 response to external stimulus
2.79 2.28e-02 GO:0051128 regulation of cellular component organization
2.96 2.48e-02 GO:0016265 death
2.58 3.11e-02 GO:0042981 regulation of apoptosis
5.69 3.17e-02 GO:0060627 regulation of vesicle-mediated transport
1.74 3.40e-02 GO:0032502 developmental process
2.71 3.49e-02 GO:0051649 establishment of localization in cell
3.59 3.99e-02 GO:0048666 neuron development
1.83 4.63e-02 GO:0006810 transport
9.28 4.64e-02 GO:0043270 positive regulation of ion transport

Gene overrepresentation in compartment category:

enrichment p-value GO term description
1.62 9.64e-05 GO:0044444 cytoplasmic part
1.82 1.26e-04 GO:0071944 cell periphery
2.83 4.40e-04 GO:0005794 Golgi apparatus
1.77 6.88e-04 GO:0005886 plasma membrane
1.41 8.97e-04 GO:0005737 cytoplasm
1.39 2.62e-03 GO:0016020 membrane
2.47 1.46e-02 GO:0044421 extracellular region part
4.96 1.51e-02 GO:0045121 membrane raft
3.95 1.99e-02 GO:0044431 Golgi apparatus part
2.24 2.29e-02 GO:0031090 organelle membrane

Gene overrepresentation in function category:

enrichment p-value GO term description
1.62 1.05e-04 GO:0005515 protein binding
4.73 2.26e-03 GO:0004857 enzyme inhibitor activity
51.79 4.02e-03 GO:0031702 type 1 angiotensin receptor binding
15.24 4.06e-03 GO:0015179 L-amino acid transmembrane transporter activity
1.28 9.97e-03 GO:0005488 binding
38.84 1.11e-02 GO:0031701 angiotensin receptor binding
34.53 1.65e-02 GO:0005313 L-glutamate transmembrane transporter activity
31.08 2.34e-02 GO:0015172 acidic amino acid transmembrane transporter activity
5.22 3.64e-02 GO:0004866 endopeptidase inhibitor activity
5.03 4.70e-02 GO:0061135 endopeptidase regulator activity